Research Series · Systems Biology
A developing program in which biological state, identity, history, fate, comparability, developmental organization, and morphogenesis are studied as explicit relational structures on measured experimental carriers.
Program
Paper I studies lineage-resolved perturbation experiments and separates future enrichment, exact state–fate recovery, lineage fingerprinting, shared compression, replicate persistence, and molecular realization. Exact recovery concentrates near lineage identity, while future-selective alignment remains measurable below exactness.
Paper II moves from lineage fate into spatial development. Across mouse organogenesis, the visible relational architecture changes dramatically with the biological comparison context, while the aggregate developmental directional sign remains stable across the tested representation family.
The series is intentionally open. Subsequent work can carry the same relational calculus into morphogenesis, multicellular organization, tissue-scale persistence, developmental transitions, molecular mechanism, and other biological systems where measured state and future realization are separated by nontrivial structure.
Which biological relations persist across changes of state, scale, representation, and developmental context, and which distinctions are created by the way the system is observed?
Paper sequence
Published preprint · v1.1
A finite relational calculus for state, identity, history, and fate across biological systems.
Exact state–fate recovery is separated from lineage identity, shared compression, future-selective enrichment, replicate persistence, and molecular realization across several lineage-resolved perturbation systems.
Published preprint
Relational comparability, developmental direction, and representation stability across the Mouse Organogenesis Spatiotemporal Transcriptomic Atlas.
Local developmental organization changes with comparison context while the aggregate chronological directional sign persists across the tested robustness family.